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KMID : 0370219970410050559
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Yakhak Hoeji
1997 Volume.41 No. 5 p.559 ~ p.564
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Studies on the Cytotoxic Constituent of Alnus hirsuta ( SPACH ) RUPR
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배춘일/Bae CI
공재명/오정완/김현종/오갑진/박시경/정순간/조의환/Gong JM/Oh JW/Kim HJ/Oh GJ/Park SK/Chung SG/Cho EH
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Abstract
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To find out antitumor active principles from natural resources, we have evaluated various extracts from the leaves of Alnus hirsuta (Betulaceae). The ethylacetate extract of this plant was found to show a significant cytotoxicity against several kinds of cultured human solid tumor cell lines (AGS, A5 49, HCT15, SKOV3, HEP3B) in vitro. Using cytotoxicity-guided chromatographic purification of the ethylacetate extract, cytotoxic constituent:1,7-bis-(4-hydroxyphenyl)-5-(beta-D-glucopyranosyloxy)-3-heptanone, was isolated and structurally identified by physico-chemical properties and spectroscopic evidences.
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